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Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > Phospho-Ser218,222 MEK 1/2 Antibody

Phospho-Ser218,222 MEK 1/2 Antibody

Catalog # Availability Size / Price Inquiry
APR03381G 100 μl / $545

Phospho-Ser218,222 MEK 1/2 Antibody

Brand

Leading Biology

Catalog Number

APR03381G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-Ser218,222 MEK 1/2 Antibody.

Molecular Weight

45 KDa

Host

Rabbit

Species Reactivity

Mouse

Target

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser218/222 conjugated to KLH.

GeneID

UniProt ID

Summary

MEK 1 (MAP Kinase Kinase, also known as MKK) is an integral component of the MAP kinase cascade that regulates cell growth and differentiation (Ahn, 1993; Chong et al., 2003). This pathway also plays a key role in synaptic plasticity in the brain (Adams and Sweatt, 2002). Activated MEK 1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase (Kyriakis et al., 1991; Seger et al., 1991; Crews et al., 1992).

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB

Dilution

WB~~ 1:1000

Images

Western Blot of NIH 3T3 cell lysates showing specific immunolabeling of the ~45k MEK 1/2 protein phosphorylated at Ser218 and Ser222. The cells were either serum starved (Control) or incubated in the presence of serum (Serum). Immunolabeling of an additional band at ~95k was also observed.

Specification

Quantity

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