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Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > PKDCC / SGK493 Antibody (Internal)

PKDCC / SGK493 Antibody (Internal)

Catalog # Availability Size / Price Inquiry
APR02725G 50 μg / $495

PKDCC / SGK493 Antibody (Internal)

Brand

Leading Biology

Catalog Number

APR02725G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PKDCC / SGK493 Antibody (Internal).

Molecular Weight

54kDa

Cellular Localization

Antigen Cellular Localization: Secreted. Golgi apparatus {ECO:0000250|UniProtKB:Q5RJI4}

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Target

Human PKDCC

GeneID

UniProt ID

Function

Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity).

Summary

Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity).

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, IF, E

Dilution

IHC-P (5 μg/ml), WB (1-2 μg/ml),

Images

Immunofluorescence of VLK in rat lung tissue with VLK antibody at 5 ug/ml.

Western blot of VLK in human lung tissue lysate with VLK antibody at 1 ug/ml.

Anti-PKDCC antibody IHC of human brain, cerebellum.

Specification

Quantity

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