> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > LIME1 / LIME Antibody (aa141-295)Brand |
Leading Biology | Catalog Number |
APR02587G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality LIME1 / LIME Antibody (aa141-295).
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Molecular Weight |
31kDa
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Cellular Localization |
Antigen Cellular Localization:
Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts Recruited to the immunological synapse upon conjugation of T-cell with antigen-presenting cell
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Host |
Rabbit
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Species Reactivity |
Human
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Target |
Reacts with the cytoplasmic domain of LIME, a 31 kD Lck-interacting transmembrane adaptor expressed by T cells.
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Symbol |
LIME
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GeneID |
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UniProt ID |
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Function |
Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T- cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.
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Summary |
Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T- cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P
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Dilution |
IHC-P (10 μg/ml)
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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