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Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > ICSBP / IRF8 Antibody (C-Terminus)

ICSBP / IRF8 Antibody (C-Terminus)

Catalog # Availability Size / Price Inquiry
APR02271G  In Stock 50 μg / $495

ICSBP / IRF8 Antibody (C-Terminus)

Brand

Leading Biology

Catalog Number

APR02271G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ICSBP / IRF8 Antibody (C-Terminus).

Molecular Weight

48kDa

Cellular Localization

Antigen Cellular Localization: Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Target

peptide corresponding to 16 amino acids near the carboxy-terminus of human IRF8

Symbol

ICSBP1

GeneID

UniProt ID

Function

Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity).

Summary

Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity).

Form

Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, IF

Dilution

IHC-P (5 μg/ml), WB (1-2 μg/ml),

Images

Immunofluorescence of IRF8 in K562 cells with IRF8 antibody at 10 ug/ml.

Western blot of IRF8 in human thymus tissue lysate with IRF8 antibody at 1ug/ml in (A) the...

Specification

Quantity

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