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Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > Goat Anti-Tissue Factor Pathway Inhibitor Antibody

Goat Anti-Tissue Factor Pathway Inhibitor Antibody

Catalog # Availability Size / Price Inquiry
APG00335G 0.1mg / $495

Goat Anti-Tissue Factor Pathway Inhibitor Antibody

Brand

Leading Biology

Catalog Number

APG00335G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Goat Anti-Tissue Factor Pathway Inhibitor Antibody.

Molecular Weight

35015 Da

Cellular Localization

Antigen Cellular Localization: Isoform Alpha: Secreted.

Host

Goat

Species Reactivity

Human

Isotype

IgG

Symbol

LACI, TFPI1

GeneID

UniProt ID

Function

Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.

Summary

This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed.

Form

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Images

HEK293 overexpressing TFPI (RC219033) and probed with APG00335G (mock transfection in first lane), tested by Origene.

APG00335G staining (0.3 μg/ml) of Hela lysate (RIPA buffer, 35 μg total protein cells per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

Specification

Quantity

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