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APG10/ATG10 Antibody

Catalog # Availability Size / Price Inquiry
APR00221G 100 μg / $495

APG10/ATG10 Antibody

Brand

Leading Biology

Catalog Number

APR00221G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality APG10/ATG10 Antibody.

Molecular Weight

18414 Da

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Target

APG10/ATG10

Isotype

Rabbit IgG

Symbol

C1orf90

GeneID

UniProt ID

Summary

Autophagy, the process of bulk degradation of cellular proteins thro μgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) thro μgh phosphorylation of autophagy protein APG1. Another member of the autophagy protein family is APG10 (Also called ATG10, APG10L), an E2-like enzyme involved in two ubiquitin-like modifications essential for autophagosome formation: ATG12-ATG5 conj μgation and the modification of a soluble form of MAP-LC3, a homolog of yeast Apg8, to a membrane-bound form. ATG10 has also been shown to interact with ATG12 in human embryonic kidney cells in the presence of ATG7. Multiple isoforms of ATG10 are known to exist.

Form

Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB

Images

Specification

Quantity

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