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HSF1 Antibody

Catalog # Availability Size / Price Inquiry
APR00203G 100 μg / $495

HSF1 Antibody

Brand

Leading Biology

Catalog Number

APR00203G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality HSF1 Antibody.

Molecular Weight

57223 Da

Cellular Localization

Antigen Cellular Localization: Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth. On activation, translocates to nuclear stress granules. Colocalizes with SUMO1 in nuclear stress granules (By similarity)

Host

Rabbit

Species Reactivity

Human, Mouse

Target

HSF

Isotype

Rabbit IgG

GeneID

UniProt ID

Function

DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

Summary

HSF 1 responds to cellular stress signals such as heat, heavy metals and oxidative reagents. It binds to heat shock response elements in the upstream region of heat shock gene and activates transcription. Upon activation, HSF 1 is trimerized and is localized in the nucleus where it binds the DNA.

Form

Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB

Images

Western blot analysis of HSF-1 expression in lysates from 3T3 cells (Lane 1) and Jurkat cells (Lane 2,3).

Specification

Quantity

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