> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > Beclin 1 AntibodyBrand |
Leading Biology | Catalog Number |
APR00157G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Beclin 1 Antibody.
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Molecular Weight |
51589 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Interaction with ATG14 promotes translocation to autophagosomes (By similarity) Expressed in dendrites and cell bodies of cerebellar Purkinje cells.
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Host |
Rabbit
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Species Reactivity |
Human, Mouse
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Target |
Beclin 1
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Isotype |
Rabbit IgG
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GeneID |
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UniProt ID |
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Function |
Plays a central role in autophagy (PubMed:10604474, PubMed:12372286, PubMed:19270693). Required for the abcission step in cytokinesis. May play a role in antiviral host defense (By similarity).
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Summary |
Beclin is a Bcl-2 binding protein. Its structure includes a Bcl-2 binding coiled-coil region, and a leucine-rich nuclear export signal (NES). Beclin protein colocalizes with intracytoplasmic organelles and nuclei in normal COS7 and MCF7 cells. Beclin interaction with Bcl-2 may be involved with host viral defense, since over expression of beclin inhibits Sindbis virus replication and expression of beclin lacking the Bcl-2 binding domain has no antiviral effects.
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Form |
Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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