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MOX1 (Meox1) Antibody (C-term)

Catalog # Availability Size / Price Inquiry
APR05874G 100 μl / $495

MOX1 (Meox1) Antibody (C-term)

Brand

Leading Biology

Catalog Number

APR05874G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MOX1 (Meox1) Antibody (C-term).

Molecular Weight

27997 Da

Cellular Localization

Antigen Cellular Localization: Nucleus {ECO:0000250|UniProtKB:P32442}. Cytoplasm {ECO:0000250|UniProtKB:P32442}. Note=Localizes predominantly in the nucleus. {ECO:0000250|UniProtKB:P32442}

Host

Rabbit

Species Reactivity

Human

Immunogen

223-254 aa

Target

This MOX1 (Meox1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-254 amino acids from the C-terminal region of human MOX1 (Meox1).

Isotype

Rabbit Ig

Symbol

MOX1

GeneID

UniProt ID

Function

Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.

Summary

Meox1 is a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. This protein may play a role in the molecular signaling network regulating somite development.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Dilution

WB~~1:1000

Images

Meox1 Antibody (C-term) (Cat. APR05874G) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the Meox1 antibody detected the Meox1 protein (arrow).

Specification

Quantity

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