> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > TRIM25 Antibody (Center)Brand |
Leading Biology | Catalog Number |
APR04146G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TRIM25 Antibody (Center).
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Molecular Weight |
70973 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Note=Colocalized with DDX58 at cytoplasmic perinuclear bodies
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
277-306 aa
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Target |
This TRIM25 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-306 amino acids from the Central region of human TRIM25.
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Isotype |
Rabbit Ig
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Symbol |
EFP, RNF147, ZNF147
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GeneID |
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UniProt ID |
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Function |
Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs.
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Summary |
The protein encoded by this gene is a member of thetripartite motif (TRIM) family. The TRIM motif includes threezinc-binding domains, a RING, a B-box type 1 and a B-box type 2,and a coiled-coil region. The protein localizes to the cytoplasm.The presence of potential DNA-binding anddimerization-transactivation domains suggests that this protein mayact as a transcription factor, similar to several other members ofthe TRIM family. Expression of the gene is upregulated in responseto estrogen, and it is thought to mediate estrogen actions inbreast cancer as a primary response gene.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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