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MMP3 Antibody (N-term)

Catalog # Availability Size / Price Inquiry
APR03830G 100 μl / $495

MMP3 Antibody (N-term)

Brand

Leading Biology

Catalog Number

APR03830G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MMP3 Antibody (N-term).

Molecular Weight

53977 Da

Cellular Localization

Antigen Cellular Localization: Secreted, extracellular space, extracellular matrix

Host

Rabbit

Species Reactivity

Human

Immunogen

30-59 aa

Target

This MMP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-59 amino acids from the N-terminal region of human MMP3.

Isotype

Rabbit Ig

Symbol

STMY1

GeneID

UniProt ID

Function

Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.

Summary

Proteins of the matrix metalloproteinase (MMP) family areinvolved in the breakdown of extracellular matrix in normalphysiological processes, such as embryonic development,reproduction, and tissue remodeling, as well as in diseaseprocesses, such as arthritis and metastasis. Most MMP's aresecreted as inactive proproteins which are activated when cleavedby extracellular proteinases. This gene encodes an enzyme whichdegrades fibronectin, laminin, collagens III, IV, IX, and X, andcartilage proteoglycans. The enzyme is thought to be involved inwound repair, progression of atherosclerosis, and tumor initiation.The gene is part of a cluster of MMP genes which localize tochromosome 11q22.3.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, IF, E

Dilution

WB~~1:1000 IHC-P~~1:10~50 IF~~1:10~50

Images

Western blot analysis of lysates from HepG2,NCI-H460,Raji,Ramos cell line (from left to right),using MMP3 Antibody (N-term)(Cat. APR03830G).APR03830G was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.

MMP3 Antibody (N-term) (Cat. APR03830G)immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MMP3 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

MMP3 Antibody (N-term) (Cat. APR03830G)immunohistochemistry analysis in formalin fixed and paraffin embedded human esophagus carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MMP3 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Specification

Quantity

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