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MME Antibody (Center)

APR03424G Product Datasheet Protocol

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APR03424G		100 μl / $495

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MME Antibody (Center)

Brand	Leading Biology	Catalog Number	APR03424G
Product Type	Polyclonal Antibodies	Field of Research
Product Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MME Antibody (Center).
Molecular Weight	85514 Da
Cellular Localization	Antigen Cellular Localization: Cell membrane; Single-pass type II membrane protein
Host	Rabbit
Species Reactivity	Human, Mouse
Immunogen	721-747 aa
Target	This MME antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 721-747 amino acids from the C-terminal region of human MME.
Isotype	Rabbit Ig
Symbol	EPN
GeneID	4311
UniProt ID	P08473
Function	Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).
Summary	This gene encodes a common acute lymphocytic leukemiaantigen that is an important cell surface marker in the diagnosisof human acute lymphocytic leukemia (ALL). This protein is presenton leukemic cells of pre-B phenotype, which represent 85% of casesof ALL. This protein is not restricted to leukemic cells, however,and is found on a variety of normal tissues. It is a glycoproteinthat is particularly abundant in kidney, where it is present on thebrush border of proximal tubules and on glomerular epithelium. Theprotein is a neutral endopeptidase that cleaves peptides at theamino side of hydrophobic residues and inactivates several peptidehormones including glucagon, enkephalins, substance P, neurotensin,oxytocin, and bradykinin. This gene, which encodes a 100-kD type IItransmembrane glycoprotein, exists in a single copy of greater than45 kb. The 5' untranslated region of this gene is alternativelyspliced, resulting in four separate mRNA transcripts. The codingregion is not affected by alternative splicing. [provided byRefSeq].
Storage & Stability	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Applications	WB, IHC-P, E
Dilution	WB~~1:1000 IHC-P~~1:50~100
Images	MME Antibody (C-term) (Cat. APR03424G) western blot analysis in LNCaP cell line lysates (35ug/lane).This demonstrates the MME antibody detected the MME protein (arrow). MME Antibody (C-term) (Cat. APR03424G) immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MME Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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