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MICAL2 Antibody (N-term)

Catalog # Availability Size / Price Inquiry
APR06180G 100 μl / $495

MICAL2 Antibody (N-term)

Brand

Leading Biology

Catalog Number

APR06180G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MICAL2 Antibody (N-term).

Molecular Weight

126689 Da

Cellular Localization

Antigen Cellular Localization: Nucleus.

Host

Rabbit

Species Reactivity

Human

Immunogen

55-83 aa

Target

This MICAL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the N-terminal region of human MICAL2.

Isotype

Rabbit Ig

Symbol

KIAA0750, MICAL2PV1, MICAL2PV2

GeneID

UniProt ID

Function

Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine- sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Dilution

WB~~1:1000

Images

Western blot analysis of MICAL2 Antibody (N-term) (Cat. APR06180G) in WiDr cell line lysates (35ug/lane). MICAL2 (arrow) was detected using the purified Pab.

Specification

Quantity

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