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FBXO4 Antibody (Center)

Catalog # Availability Size / Price Inquiry
APR06157G 100 μl / $495

FBXO4 Antibody (Center)

Brand

Leading Biology

Catalog Number

APR06157G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality FBXO4 Antibody (Center).

Molecular Weight

44136 Da

Cellular Localization

Antigen Cellular Localization: Cytoplasm.

Host

Rabbit

Species Reactivity

Human

Immunogen

225-251 aa

Target

This FBXO4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 225-251 amino acids from the Central region of human FBXO4.

Isotype

Rabbit Ig

Symbol

FBX4

GeneID

UniProt ID

Function

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1.

Summary

FBXO4 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein belongs to the Fbxs class.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Dilution

WB~~1:1000

Images

Western blot analysis of FBXO4 Antibody (Center) (Cat. APR06157G) in Y79 cell line lysates (35ug/lane). FBXO4 (arrow) was detected using the purified Pab.

Specification

Quantity

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