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PEA-15 Antibody (C-term)

Catalog # Availability Size / Price Inquiry
APR06089G 100 μl / $495

PEA-15 Antibody (C-term)

Brand

Leading Biology

Catalog Number

APR06089G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PEA-15 Antibody (C-term).

Molecular Weight

15040 Da

Cellular Localization

Antigen Cellular Localization: Cytoplasm. Note=Associated with microtubules

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

86-115 aa

Target

This PEA-15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-115 amino acids from the C-terminal region of human PEA-15.

Isotype

Rabbit Ig

GeneID

UniProt ID

Function

Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.

Summary

PEA15 is a death effector domain (DED)-containing protein predominantly expressed in the central nervous system, particularly in astrocytes.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, FC, E

Dilution

WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50

Images

Western blot analysis of PEA-15 Antibody (C-term) (Cat. APR06089G) in T47D cell line lysates (35ug/lane).PEA-15 (arrow) was detected using the purified Pab.

Western blot analysis of PEA-15 Antibody (C-term) (Cat. APR06089G) in mouse lung tissue lysates (35ug/lane).PEA-15 (arrow) was detected using the purified Pab.

Formalin-fixed and paraffin-embedded mouse heart tissue reacted with PEA-15 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Specification

Quantity

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