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Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > Phospho-mouse TSC1(T416) Antibody

Phospho-mouse TSC1(T416) Antibody

Catalog # Availability Size / Price Inquiry
APR05343G 100 μl / $495

Phospho-mouse TSC1(T416) Antibody

Brand

Leading Biology

Catalog Number

APR05343G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-mouse TSC1(T416) Antibody.

Molecular Weight

128746 Da

Cellular Localization

Antigen Cellular Localization: Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes.

Host

Rabbit

Species Reactivity

Mouse

Target

This mouse TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T416 of mouse TSC1.

Isotype

Rabbit Ig

Symbol

Kiaa0243

GeneID

UniProt ID

Function

In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).

Summary

In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

DB, E

Dilution

DB~~1:500

Images

Dot blot analysis of Mouse TSC1 Antibody (Phospho T416) Phospho-specific Pab (Cat. APR05343G) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.

Specification

Quantity

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