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MCM9 Antibody (C-term)

Catalog # Availability Size / Price Inquiry
APR04542G 100 μl / $495

MCM9 Antibody (C-term)

Brand

Leading Biology

Catalog Number

APR04542G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MCM9 Antibody (C-term).

Molecular Weight

127313 Da

Cellular Localization

Antigen Cellular Localization: Nucleus. Note=Localizes to nuclear foci and colocalizes with RAD51.

Host

Rabbit

Species Reactivity

Human

Immunogen

316-345 aa

Target

This MCM9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 316-345 amino acids from the C-terminal region of human MCM9.

Isotype

Rabbit Ig

Symbol

C6orf61, MCMDC1

GeneID

UniProt ID

Function

Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8- MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart.

Summary

MCM9, a member of the MCM2-8 family, binds to chromatin and is required for the recruitment of the MCM2-7 helicase onto chromatin. MCM9 can form a complex with Cdt1. It is thought that MCM9 might play an important role in DNA replication since its depletion results in its inhibition.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Dilution

WB~~1:1000

Images

All lanes : Anti-MCM9 Antibody (C-term) at 1:1000 dilution Lane 1: 293 whole cell lysate Lane 2: K562 whole cell lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 127 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

Specification

Quantity

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