> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > SMAD1 Antibody (N-term)Brand |
Leading Biology | Catalog Number |
APR04519G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality SMAD1 Antibody (N-term).
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Molecular Weight |
52260 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
1-30 aa
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Target |
This SMAD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SMAD1.
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Isotype |
Rabbit Ig
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Symbol |
BSP1, MADH1, MADR1
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GeneID |
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UniProt ID |
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Function |
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.
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Summary |
The protein encoded by this gene belongs to the SMAD, afamily of proteins similar to the gene products of the Drosophilagene 'mothers against decapentaplegic' (Mad) and the C. elegansgene Sma. SMAD proteins are signal transducers and transcriptionalmodulators that mediate multiple signaling pathways. This proteinmediates the signals of the bone morphogenetic proteins (BMPs),which are involved in a range of biological activities includingcell growth, apoptosis, morphogenesis, development and immuneresponses. In response to BMP ligands, this protein can bephosphorylated and activated by the BMP receptor kinase. Thephosphorylated form of this protein forms a complex with SMAD4,which is important for its function in the transcriptionregulation. This protein is a target for SMAD-specific E3 ubiquitinligases, such as SMURF1 and SMURF2, and undergoes ubiquitinationand proteasome-mediated degradation. Alternatively splicedtranscript variants encoding the same protein have been observed.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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