> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > CASQ2 Antibody (Center)Brand |
Leading Biology | Catalog Number |
APR04494G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CASQ2 Antibody (Center).
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Molecular Weight |
46436 Da
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Cellular Localization |
Antigen Cellular Localization:
Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:O09161}. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells {ECO:0000250|UniProtKB:O09161}
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
79-107 aa
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Target |
This CASQ2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-107 amino acids from the Central region of human CASQ2.
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Isotype |
Rabbit Ig
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GeneID |
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UniProt ID |
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Function |
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
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Summary |
The protein encoded by this gene specifies the cardiacmuscle family member of the calsequestrin family. Calsequestrin islocalized to the sarcoplasmic reticulum in cardiac and slowskeletal muscle cells. The protein is a calcium binding proteinthat stores calcium for muscle function. Mutations in this genecause stress-induced polymorphic ventricular tachycardia, alsoreferred to as catecholaminergic polymorphic ventriculartachycardia 2 (CPVT2), a disease characterized by bidirectionalventricular tachycardia that may lead to cardiac arrest. [providedby RefSeq].
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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