> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > MKRN1 Antibody(Center)Brand |
Leading Biology | Catalog Number |
APR04460G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MKRN1 Antibody(Center).
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Molecular Weight |
53349 Da
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
184-213 aa
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Target |
This MKRN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 184-213 amino acids from the Central region of human MKRN1.
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Isotype |
Rabbit Ig
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Symbol |
RNF61
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GeneID |
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UniProt ID |
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Function |
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.
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Summary |
The Makorin ring finger protein-1 gene (MKRN1) is a highlytranscribed, intron-containing source for a family of intronlessmammalian genes encoding a novel class of zinc finger proteins.Phylogenetic analyses indicate that the MKRN1 gene is the ancestralfounder of this gene family (Gray et al., 2000 [PubMed10843807]).
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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