> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > F12 Antibody (N-term)Brand |
Leading Biology | Catalog Number |
APR04412G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality F12 Antibody (N-term).
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Molecular Weight |
67792 Da
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Cellular Localization |
Antigen Cellular Localization:
Secreted.
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
9-38 aa
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Target |
This F12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-38 amino acids from the N-terminal region of human F12.
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Isotype |
Rabbit Ig
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GeneID |
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UniProt ID |
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Function |
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta- factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.
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Summary |
This gene encodes coagulation factor XII which circulatesin blood as a zymogen. This single chain zymogen is converted to atwo-chain serine protease with an heavy chain (alpha-factor XIIa)and a light chain. The heavy chain contains two fibronectin-typedomains, two epidermal growth factor (EGF)-like domains, a kringledomain and a proline-rich domain, whereas the light chain containsonly a catalytic domain. On activation, further cleavages takesplace in the heavy chain, resulting in the production ofbeta-factor XIIa light chain and the alpha-factor XIIa light chainbecomes beta-factor XIIa heavy chain. Prekallikrein is cleaved byfactor XII to form kallikrein, which then cleaves factor XII firstto alpha-factor XIIa and then to beta-factor XIIa. The activefactor XIIa participates in the initiation of blood coagulation,fibrinolysis, and the generation of bradykinin and angiotensin. Itactivates coagulation factors VII and XI. Defects in this gene donot cause any clinical symptoms and the sole effect is thatwhole-blood clotting time is prolonged.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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