> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > LCP1 Antibody (Center)Brand |
Leading Biology | Catalog Number |
APR04365G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality LCP1 Antibody (Center).
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Molecular Weight |
70288 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm, cytoskeleton. Cell junction. Cell projection. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Relocalizes to the immunological synapse between peripheral blood T-lymphocytes and antibody-presenting cells in response to costimulation through TCR/CD3 and CD2 or CD28. Associated with the actin cytoskeleton at membrane ruffles (By similarity). Relocalizes to actin-rich cell projections upon serine phosphorylation.
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
306-335 aa
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Target |
This LCP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-335 amino acids from the Central region of human LCP1.
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Isotype |
Rabbit Ig
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Symbol |
PLS2
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GeneID |
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UniProt ID |
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Function |
Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.
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Summary |
Plastins are a family of actin-binding proteins that areconserved throughout eukaryote evolution and expressed in mosttissues of higher eukaryotes. In humans, two ubiquitous plastinisoforms (L and T) have been identified. Plastin 1 (otherwise knownas Fimbrin) is a third distinct plastin isoform which isspecifically expressed at high levels in the small intestine. The Lisoform is expressed only in hemopoietic cell lineages, while the Tisoform has been found in all other normal cells of solid tissuesthat have replicative potential (fibroblasts, endothelial cells,epithelial cells, melanocytes, etc.). However, L-plastin has beenfound in many types of malignant human cells of non-hemopoieticorigin suggesting that its expression is induced accompanyingtumorigenesis in solid tissues.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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