> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > NCAPH Antibody (Center)Brand |
Leading Biology | Catalog Number |
APR04363G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality NCAPH Antibody (Center).
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Molecular Weight |
82563 Da
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Cellular Localization |
Antigen Cellular Localization:
Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
354-382 aa
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Target |
This NCAPH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 354-382 amino acids from the Central region of human NCAPH.
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Isotype |
Rabbit Ig
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Symbol |
BRRN, BRRN1, CAPH, KIAA0074
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GeneID |
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UniProt ID |
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Function |
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
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Summary |
This gene encodes a member of the barr gene family and aregulatory subunit of the condensin complex. This complex isrequired for the conversion of interphase chromatin into condensedchromosomes. The protein encoded by this gene is associated withmitotic chromosomes, except during the early phase of chromosomecondensation. During interphase, the protein has a distinctpunctate nucleolar localization.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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