> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > CLEC6A Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR04355G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CLEC6A Antibody (C-term).
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Molecular Weight |
23998 Da
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Cellular Localization |
Antigen Cellular Localization:
Membrane; Single-pass type II membrane protein
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
137-163 aa
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Target |
This CLEC6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-163 amino acids from the C-terminal region of human CLEC6A.
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Isotype |
Rabbit Ig
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Symbol |
CLECSF10, DECTIN2
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GeneID |
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UniProt ID |
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Function |
Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9- NF-kappa-B-dependent pathway (By similarity).
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Summary |
Like dectin-1 (CLEC7A; MIM 606264), CLEC6A, or dectin-2,is a type II membrane receptor with an extracellular C-typelectin-like domain fold. However, unlike dectin-1, dectin-2 lacksan immunoreceptor tyrosine-based activation motif (ITAM) in itscytoplasmic domain (Kanazawa et al., 2004 [PubMed15175046]).
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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| 6 | Leading Biology | APR03502G | IGHG1 Antibody (Center) | 100 μl | Polyclonal Antibodies |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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