> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > GNAS Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR04328G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality GNAS Antibody (C-term).
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Molecular Weight |
28029 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Neuroendocrine secretory granules.
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
217-244 aa
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Target |
This GNAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-244 amino acids from the C-terminal region of human GNAS.
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Isotype |
Rabbit Ig
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GeneID |
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UniProt ID |
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Summary |
This locus has a highly complex imprinted expressionpattern. It gives rise to maternally, paternally, and biallelicallyexpressed transcripts that are derived from four alternativepromoters and 5' exons. Some transcripts contains a differentiallymethylated region (DMR) at their 5' exons, and this DMR is commonlyfound in imprinted genes and correlates with transcript expression.An antisense transcript is produced from an overlapping locus onthe opposite strand. One of the transcripts produced from thislocus, and the antisense transcript, are paternally expressednoncoding RNAs, and may regulate imprinting in this region. Inaddition, one of the transcripts contains a second overlapping ORF,which encodes a structurally unrelated protein - Alex. Alternativesplicing of downstream exons is also observed, which results indifferent forms of the stimulatory G-protein alpha subunit, a keyelement of the classical signal transduction pathway linkingreceptor-ligand interactions with the activation of adenylylcyclase and a variety of cellular reponses. Multiple transcriptvariants encoding different isoforms have been found for this gene.Mutations in this gene result in pseudohypoparathyroidism type 1a,pseudohypoparathyroidism type 1b, Albright hereditaryosteodystrophy, pseudopseudohypoparathyroidism, McCune-Albrightsyndrome, progressive osseus heteroplasia, polyostotic fibrousdysplasia of bone, and some pituitary tumors.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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