> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > AGTRAP Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR04313G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality AGTRAP Antibody (C-term).
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Molecular Weight |
17419 Da
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Cellular Localization |
Antigen Cellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
133-159 aa
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Target |
This AGTRAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-159 amino acids from the C-terminal region of human AGTRAP.
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Isotype |
Rabbit Ig
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Symbol |
ATRAP
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GeneID |
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UniProt ID |
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Function |
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
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Summary |
This gene encodes a transmembrane protein localized to theplasma membrane and perinuclear vesicular structures. The geneproduct interacts with the angiotensin II type I receptor andnegatively regulates angiotensin II signaling. Alternative splicingof this gene generates multiple transcript variants encodingdifferent isoforms.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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