> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > EDA2R Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR04308G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality EDA2R Antibody (C-term).
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Molecular Weight |
32759 Da
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Cellular Localization |
Antigen Cellular Localization:
Membrane; Single-pass type III membrane protein
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
267-297 aa
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Target |
This EDA2R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-297 amino acids from the C-terminal region of human EDA2R.
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Isotype |
Rabbit Ig
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Symbol |
TNFRSF27, XEDAR
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GeneID |
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UniProt ID |
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Function |
Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.
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Summary |
EDA-A1 and EDA-A2 are two isoforms of ectodysplasin thatare encoded by the anhidrotic ectodermal dysplasia (EDA) gene.Mutations in EDA give rise to a clinical syndrome characterized byloss of hair, sweat glands, and teeth. The protein encoded by thisgene specifically binds to EDA-A2 isoform. This protein is a typeIII transmembrane protein of the TNFR (tumor necrosis factorreceptor) superfamily, and contains 3 cysteine-rich repeats and asingle transmembrane domain but lacks an N-terminal signal peptide.Multiple alternatively spliced transcript variants have been foundfor this gene, but some variants lack sufficient support. [providedby RefSeq].
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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