> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > ZFP57 Antibody (Center)Brand |
Leading Biology | Catalog Number |
APR04298G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ZFP57 Antibody (Center).
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Molecular Weight |
51919 Da
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Cellular Localization |
Antigen Cellular Localization:
Nucleus. Note=Binds various differentially methylated regions (DMR), including the SNRPN DMR
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
269-296 aa
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Target |
This ZFP57 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 269-296 amino acids from the Central region of human ZFP57.
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Isotype |
Rabbit Ig
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Symbol |
C6orf40, ZNF698
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GeneID |
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UniProt ID |
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Function |
Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity). Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells.
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Summary |
The protein encoded by this gene is a zinc finger proteincontaining a KRAB domain. Studies in mouse suggest that thisprotein may function as a transcriptional repressor. Mutations inthis gene have been associated with transient neonatal diabetesmellitus type 1 (TNDM1).
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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