> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > NOG Antibody (Center)Brand |
Leading Biology | Catalog Number |
APR04286G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality NOG Antibody (Center).
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Molecular Weight |
25774 Da
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Cellular Localization |
Antigen Cellular Localization:
Secreted.
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Host |
Rabbit
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Species Reactivity |
Human, Mouse
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Immunogen |
84-111 aa
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Target |
This NOG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-111 amino acids from the Central region of human NOG.
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Isotype |
Rabbit Ig
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GeneID |
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UniProt ID |
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Function |
Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.
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Summary |
The secreted polypeptide, encoded by this gene, binds andinactivates members of the transforming growth factor-beta(TGF-beta) superfamily signaling proteins, such as bonemorphogenetic protein-4 (BMP4). By diffusing through extracellularmatrices more efficiently than members of the TGF-beta superfamily,this protein may have a principal role in creating morphogenicgradients. The protein appears to have pleiotropic effect, bothearly in development as well as in later stages. It was originallyisolated from Xenopus based on its ability to restore normaldorsal-ventral body axis in embryos that had been artificiallyventralized by UV treatment. The results of the mouse knockout ofthe ortholog suggest that it is involved in numerous developmentalprocesses, such as neural tube fusion and joint formation.Recently, several dominant human NOG mutations in unrelatedfamilies with proximal symphalangism (SYM1) and multiple synostosessyndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiplejoint fusion as their principal feature, and map to the same region(17q22) as this gene. All of these mutations altered evolutionarilyconserved amino acid residues. The amino acid sequence of thishuman gene is highly homologous to that of Xenopus, rat and mouse.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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