> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > ZFP36L2 Antibody (Center)Brand |
Leading Biology | Catalog Number |
APR04237G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ZFP36L2 Antibody (Center).
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Molecular Weight |
51063 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
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Host |
Rabbit
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Species Reactivity |
Human, Mouse
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Immunogen |
166-193 aa
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Target |
This ZFP36L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-193 amino acids from the Central region of human ZFP36L2.
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Isotype |
Rabbit Ig
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Symbol |
BRF2, ERF2, RNF162C, TIS11D
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GeneID |
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UniProt ID |
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Function |
mRNA-binding protein that plays a key role in self- renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3'-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit- erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation (By similarity).
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Summary |
This gene is a member of the TIS11 family of earlyresponse genes. Family members are induced by various agonists suchas the phorbol ester TPA and the polypeptide mitogen EGF. Theencoded protein contains a distinguishing putative zinc fingerdomain with a repeating cys-his motif. This putative nucleartranscription factor most likely functions in regulating theresponse to growth factors.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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