> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > ZP3 Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR04197G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ZP3 Antibody (C-term).
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Molecular Weight |
47018 Da
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Cellular Localization |
Antigen Cellular Localization:
Processed zona pellucida sperm-binding protein 3: Secreted, extracellular space, extracellular matrix Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
353-380 aa
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Target |
This ZP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 353-380 amino acids from the C-terminal region of human ZP3.
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Isotype |
Rabbit Ig
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Symbol |
ZP3A, ZP3B, ZPC
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GeneID |
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UniProt ID |
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Function |
The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
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Summary |
The zona pellucida is an extracellular matrix thatsurrounds the oocyte and early embryo. It is composed primarily ofthree or four glycoproteins with various functions duringfertilization and preimplantation development. The protein encodedby this gene is a structural component of the zona pellucida andfunctions in primary binding and induction of the sperm acrosomereaction. The nascent protein contains a N-terminal signal peptidesequence, a conserved ZP domain, a C-terminal consensus furincleavage site, and a transmembrane domain. It is hypothesized thatfurin cleavage results in release of the mature protein from theplasma membrane for subsequent incorporation into the zonapellucida matrix. However, the requirement for furin cleavage inthis process remains controversial based on mouse studies. Avariation in the last exon of this gene has previously served asthe basis for an additional ZP3 locus; however, sequence andliterature review reveals that there is only one full-length ZP3locus in the human genome. Another locus encoding a bipartitetranscript designated POMZP3 contains a duplication of the lastfour exons of ZP3, including the above described variation, andmaps closely to this gene.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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