> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > USP10 Antibody (Center)Brand |
Leading Biology | Catalog Number |
APR04188G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality USP10 Antibody (Center).
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Molecular Weight |
87134 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Nucleus. Early endosome. Note=Cytoplasmic in normal conditions. After DNA damage, translocates to the nucleus following phosphorylation by ATM
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
500-529 aa
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Target |
This USP10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 500-529 amino acids from the Central region of human USP10.
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Isotype |
Rabbit Ig
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Symbol |
KIAA0190
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GeneID |
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UniProt ID |
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Function |
Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34- containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling.
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Summary |
Ubiquitin is a highly conserved protein that is covalentlylinked to other proteins to regulate their function anddegradation. This gene encodes a member of the ubiquitin-specificprotease family of cysteine proteases. The enzyme specificallycleaves ubiquitin from ubiquitin-conjugated protein substrates. Theprotein is found in the nucleus and cytoplasm. It functions as aco-factor of the DNA-bound androgen receptor complex, and isinhibited by a protein in the Ras-GTPase pathway. The human genomecontains several pseudogenes similar to this gene. [provided byRefSeq].
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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