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DSC3 Antibody (C-term)

Catalog # Availability Size / Price Inquiry
APR04137G 100 μl / $495

DSC3 Antibody (C-term)

Brand

Leading Biology

Catalog Number

APR04137G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality DSC3 Antibody (C-term).

Molecular Weight

99969 Da

Cellular Localization

Antigen Cellular Localization: Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome

Host

Rabbit

Species Reactivity

Human

Immunogen

822-850 aa

Target

This DSC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 822-850 amino acids from the C-terminal region of human DSC3.

Isotype

Rabbit Ig

Symbol

CDHF3, DSC4

GeneID

UniProt ID

Function

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.

Summary

The protein encoded by this gene is a calcium-dependentglycoprotein that is a member of the desmocollin subfamily of thecadherin superfamily. These desmosomal family members, along withthe desmogleins, are found primarily in epithelial cells where theyconstitute the adhesive proteins of the desmosome cell-celljunction and are required for cell adhesion and desmosomeformation. The desmosomal family members are arranged in twoclusters on chromosome 18, occupying less than 650 kb combined.Alternative splicing results in two transcript variants encodingdistinct isoforms.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Dilution

WB~~1:1000

Images

Western blot analysis of lysate from A431 cell line, using DSC3 Antibody (C-term)(Cat. APR04137G). APR04137G was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.

Specification

Quantity

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