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KLHL25 Antibody (N-term)

Catalog # Availability Size / Price Inquiry
APR04105G 100 μl / $495

KLHL25 Antibody (N-term)

Brand

Leading Biology

Catalog Number

APR04105G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality KLHL25 Antibody (N-term).

Molecular Weight

65923 Da

Host

Rabbit

Species Reactivity

Human

Immunogen

62-91 aa

Target

This KLHL25 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-91 amino acids from the N-terminal region of human KLHL25.

Isotype

Rabbit Ig

Symbol

ENC2

GeneID

UniProt ID

Function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Dilution

WB~~1:1000

Images

KLHL25 Antibody (N-term) (Cat. APR04105G) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the KLHL25 antibody detected the KLHL25 protein (arrow).

Specification

Quantity

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