> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > BAG4 Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR04095G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality BAG4 Antibody (C-term).
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Molecular Weight |
49594 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm.
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
381-409 aa
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Target |
This BAG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-409 amino acids from the C-terminal region of human BAG4.
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Isotype |
Rabbit Ig
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Symbol |
SODD
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GeneID |
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UniProt ID |
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Function |
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PARK2 translocation to damaged mitochondria.
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Summary |
BAG4 is a member of theBAG1-related protein family. BAG1 is an anti-apoptotic protein thatfunctions through interactions with a variety of cell apoptosis andgrowth related proteins including BCL-2, Raf-protein kinase,steroid hormone receptors, growth factor receptors and members ofthe heat shock protein 70 kDa family. This protein contains a BAGdomain near the C-terminus, which could bind and inhibit thechaperone activity of Hsc70/Hsp70. This protein was found to beassociated with the death domain of tumor necrosis factor receptortype 1 (TNF-R1) and death receptor-3 (DR3), and thereby negativelyregulates downstream cell death signaling. The regulatory role ofthis protein in cell death was demonstrated in epithelial cellswhich undergo apoptosis while integrin mediated matrix contacts arelost.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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| Select | Brand | Catalog No. | Product Name | Pack Size | Type | Field of Research | Specification | Quantity | Price(USD) | |
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| 2 | Leading Biology | APR04537G | CMIP Antibody (C-term) | 100 μl | Polyclonal Antibodies |
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| 3 | Leading Biology | APR12422G | Human H4 Histamine Receptor (extracellular) Antibody | 50 μl | Polyclonal Antibodies |
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| 4 | Leading Biology | APR03844G | UBE2W Antibody (C-term) | 100 μl | Polyclonal Antibodies |
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| 5 | Leading Biology | APR04349G | HECTD2 Antibody (N-term) | 100 μl | Polyclonal Antibodies |
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| 6 | Leading Biology | APR03502G | IGHG1 Antibody (Center) | 100 μl | Polyclonal Antibodies |
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$495.00 | Add Ask |
Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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