> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > TRAF4 Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR04065G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TRAF4 Antibody (C-term).
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Molecular Weight |
53543 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
427-455 aa
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Target |
This TRAF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 427-455 amino acids from the C-terminal region of human TRAF4.
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Isotype |
Rabbit Ig
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Symbol |
CART1, MLN62, RNF83
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GeneID |
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UniProt ID |
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Function |
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.
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Summary |
This gene encodes a member of the TNF receptor associatedfactor (TRAF) family. TRAF proteins are associated with, andmediate signal transduction from members of the TNF receptorsuperfamily. The encoded protein has been shown to interact withneurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTRinduced cell death and NF-kappa B activation. This protein has beenfound to bind to p47phox, a cytosolic regulatory factor included ina multi-protein complex known as NAD(P)H oxidase. This proteinthus, is thought to be involved in the oxidative activation ofMAPK8/JNK. Alternatively spliced transcript variants have beenobserved but the full-length nature of only one has beendetermined.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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| 5 | Leading Biology | APR04349G | HECTD2 Antibody (N-term) | 100 μl | Polyclonal Antibodies |
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| 6 | Leading Biology | APR03502G | IGHG1 Antibody (Center) | 100 μl | Polyclonal Antibodies |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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