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Connexin 37 Antibody (C-term)

Catalog # Availability Size / Price Inquiry
APR04055G 100 μl / $495

Connexin 37 Antibody (C-term)

Brand

Leading Biology

Catalog Number

APR04055G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Connexin 37 Antibody (C-term).

Molecular Weight

37414 Da

Cellular Localization

Antigen Cellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction

Host

Rabbit

Species Reactivity

Mouse

Immunogen

303-333 aa

Target

This Connexin 37 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 303-333 amino acids from the C-terminal region of human Connexin 37.

Isotype

Rabbit Ig

GeneID

UniProt ID

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Summary

Gap junctions permit direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular communication. Gap junction channels consist of connexin protein subunits encoded by a multigene family. Erythrokeratodermia variabilis (EKV) is an autosomal dominant disorder of keratinization characterized by migratory erythematous lesions and fixed keratotic plaques. Mutations in the GJB3 gene have been reported in some but not all families, although it has been postulated that the absence of connexin 30.3 can be compensated by other connexins.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, E

Dilution

WB~~1:1000 IHC-P~~1:10~50

Images

GJA4 Antibody (K317).Connexin (Cat. APR04055G) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the GJA4 antibody detected the GJA4 protein (arrow).

Connexin 37 Antibody (GJA4) (C-term) (Cat. APR04055G)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Connexin 37 Antibody (GJA4) (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Specification

Quantity

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