> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > COPS8 Antibody (N-term)Brand |
Leading Biology | Catalog Number |
APR04050G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality COPS8 Antibody (N-term).
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Molecular Weight |
23226 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Nucleus
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
1-30 aa
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Target |
This COPS8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human COPS8.
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Isotype |
Rabbit Ig
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Symbol |
CSN8
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GeneID |
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UniProt ID |
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Function |
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
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Summary |
The protein encoded by this gene is one of the eightsubunits of COP9 signalosome, a highly conserved protein complexthat functions as an important regulator in multiple signalingpathways. The structure and function of COP9 signalosome is similarto that of the 19S regulatory particle of 26S proteasome. COP9signalosome has been shown to interact with SCF-type E3 ubiquitinligases and act as a positive regulator of E3 ubiquitin ligases.Alternatively spliced transcript variants encoding distinctisoforms have been observed.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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