> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > RIPK3 Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR03974G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality RIPK3 Antibody (C-term).
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Molecular Weight |
56887 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm, cytosol. Cell membrane Mitochondrion
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
480-509 aa
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Target |
This RIPK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 480-509 amino acids from the C-terminal region of human RIPK3.
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Isotype |
Rabbit Ig
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Symbol |
RIP3
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GeneID |
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UniProt ID |
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Function |
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
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Summary |
The product of this gene is a member of thereceptor-interacting protein (RIP) family of serine/threonineprotein kinases, and contains a C-terminal domain unique from otherRIP family members. The encoded protein is predominantly localizedto the cytoplasm, and can undergo nucleocytoplasmic shuttlingdependent on novel nuclear localization and export signals. It is acomponent of the tumor necrosis factor (TNF) receptor-I signalingcomplex, and can induce apoptosis and weakly activate the NF-kappaBtranscription factor.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, E
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Dilution |
WB~~1:1000
IHC-P~~1:10~50
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Images |
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Specification |
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Quantity |
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| 6 | Leading Biology | APR03502G | IGHG1 Antibody (Center) | 100 μl | Polyclonal Antibodies |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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