> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > STAM2 Antibody (Center)Brand |
Leading Biology | Catalog Number |
APR03900G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality STAM2 Antibody (Center).
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Molecular Weight |
58164 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
143-172 aa
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Target |
This STAM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 143-172 amino acids from the Central region of human STAM2.
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Isotype |
Rabbit Ig
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Symbol |
HBP
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GeneID |
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UniProt ID |
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Function |
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).
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Summary |
The protein encoded by this gene is closely related toSTAM, an adaptor protein involved in the downstream signaling ofcytokine receptors, both of which contain a SH3 domain and theimmunoreceptor tyrosine-based activation motif (ITAM). Similar toSTAM, this protein acts downstream of JAK kinases, and isphosphorylated in response to cytokine stimulation. This proteinand STAM thus are thought to exhibit compensatory effects on thesignaling pathway downstream of JAK kinases upon cytokinestimulation.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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| 6 | Leading Biology | APR03502G | IGHG1 Antibody (Center) | 100 μl | Polyclonal Antibodies |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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