> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > PPM1D Antibody (Center)Brand |
Leading Biology | Catalog Number |
APR03881G |
Product Type |
Polyclonal Antibodies | Field of Research |
|
Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PPM1D Antibody (Center).
|
||
Molecular Weight |
66675 Da
|
||
Host |
Rabbit
|
||
Species Reactivity |
Human
|
||
Immunogen |
183-212 aa
|
||
Target |
This PPM1D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-212 amino acids from the Central region of human PPM1D.
|
||
Isotype |
Rabbit Ig
|
||
Symbol |
WIP1
|
||
GeneID |
|||
UniProt ID |
|||
Function |
Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins.
|
||
Summary |
The protein encoded by this gene is a member of the PP2Cfamily of Ser/Thr protein phosphatases. PP2C family members areknown to be negative regulators of cell stress response pathways.The expression of this gene is induced in a p53-dependent manner inresponse to various environmental stresses. While being induced bytumor suppressor protein TP53/p53, this phosphatase negativelyregulates the activity of p38 MAP kinase, MAPK/p38, through whichit reduces the phosphorylation of p53, and in turn suppressesp53-mediated transcription and apoptosis. This phosphatase thusmediates a feedback regulation of p38-p53 signaling thatcontributes to growth inhibition and the suppression of stressinduced apoptosis. This gene is located in a chromosomal regionknown to be amplified in breast cancer. The amplification of thisgene has been detected in both breast cancer cell line and primarybreast tumors, which suggests a role of this gene in cancerdevelopment.
|
||
Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
|
||
Applications |
WB, E
|
||
Dilution |
WB~~1:1000
|
||
Images |
|
||
Specification |
|||
Quantity |
|
||
| Select | Brand | Catalog No. | Product Name | Pack Size | Type | Field of Research | Specification | Quantity | Price(USD) | |
| 1 | Leading Biology | APR03440G | ITGA11 Antibody (N-term) | 100 μl | Polyclonal Antibodies |
|
$495.00 | Add Ask | ||
| 2 | Leading Biology | APR04537G | CMIP Antibody (C-term) | 100 μl | Polyclonal Antibodies |
|
$495.00 | Add Ask | ||
| 3 | Leading Biology | APR12422G | Human H4 Histamine Receptor (extracellular) Antibody | 50 μl | Polyclonal Antibodies |
|
$695.00 | Add Ask | ||
| 4 | Leading Biology | APR03844G | UBE2W Antibody (C-term) | 100 μl | Polyclonal Antibodies |
|
$495.00 | Add Ask | ||
| 5 | Leading Biology | APR04349G | HECTD2 Antibody (N-term) | 100 μl | Polyclonal Antibodies |
|
$495.00 | Add Ask | ||
| 6 | Leading Biology | APR03502G | IGHG1 Antibody (Center) | 100 μl | Polyclonal Antibodies |
|
$495.00 | Add Ask |
Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
You have 0 item in your cart
You have 0 item in your inquiry list
