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C9 Antibody (Center)

Catalog # Availability Size / Price Inquiry
APR03866G 100 μl / $495

C9 Antibody (Center)

Brand

Leading Biology

Catalog Number

APR03866G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality C9 Antibody (Center).

Molecular Weight

63173 Da

Cellular Localization

Antigen Cellular Localization: Secreted. Cell membrane; Multi-pass membrane protein. Note=Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore

Host

Rabbit

Species Reactivity

Human

Immunogen

191-220 aa

Target

This C9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-220 amino acids from the Central region of human C9.

Isotype

Rabbit Ig

GeneID

UniProt ID

Function

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.

Summary

This gene encodes the final component of the complementsystem. It participates in the formation of the Membrane AttackComplex (MAC). The MAC assembles on bacterial membranes to form apore, permitting disruption of bacterial membrane organization.Mutations in this gene cause component C9 deficiency. [provided byRefSeq].

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, E

Dilution

WB~~1:1000 IHC-P~~1:10~50

Images

Anti-C9 Antibody (Center) at 1:1000 dilution + human liver lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 63 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

C9 Antibody (Center) (Cat. APR03866G) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the C9 antibody detected the C9 protein (arrow).

C9 Antibody (Center) (APR03866G)immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of C9 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

Specification

Quantity

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