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ITGA5 Antibody (Center)

Catalog # Availability Size / Price Inquiry
APR03661G 100 μl / $495

ITGA5 Antibody (Center)

Brand

Leading Biology

Catalog Number

APR03661G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ITGA5 Antibody (Center).

Molecular Weight

114536 Da

Cellular Localization

Antigen Cellular Localization: Membrane; Single-pass type I membrane protein

Host

Rabbit

Species Reactivity

Human

Immunogen

575-602 aa

Target

This ITGA5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 575-602 amino acids from the Central region of human ITGA5.

Isotype

Rabbit Ig

Symbol

FNRA

GeneID

UniProt ID

Function

Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Summary

The product of this gene belongs to the integrin alphachain family. Integrins are heterodimeric integral membraneproteins composed of an alpha chain and a beta chain. This geneencodes the integrin alpha 5 chain. Alpha chain 5 undergoespost-translational cleavage in the extracellular domain to yielddisulfide-linked light and heavy chains that join with beta 1 toform a fibronectin receptor. In addition to adhesion, integrins areknown to participate in cell-surface mediated signalling. [providedby RefSeq].

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, E

Dilution

WB~~1:1000 IHC-P~~1:10~50

Images

Western blot analysis of ITGA5 (arrow) using rabbit polyclonal ITGA5 Antibody (Center) (Cat. APR03661G). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ITGA5 gene.

ITGA5 Antibody (Center) (Cat. APR03661G)immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ITGA5 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

ITGA5 Antibody (Center) (Cat. APR03661G) western blot analysis in human uterine tumor and mouse bladder tissue lysates (35ug/lane).This demonstrates the ITGA5 antibody detected the ITGA5 protein (arrow).

Specification

Quantity

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