> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > PLAG1 Antibody (N-term)Brand |
Leading Biology | Catalog Number |
APR03591G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PLAG1 Antibody (N-term).
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Molecular Weight |
55909 Da
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Cellular Localization |
Antigen Cellular Localization:
Nucleus Note=Strong nucleolar localization when sumoylation is inhibited
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
8-35 aa
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Target |
This PLAG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-35 amino acids from the N-terminal region of human PLAG1.
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Isotype |
Rabbit Ig
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GeneID |
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UniProt ID |
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Function |
Transcription factor whose activation results in up- regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia.
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Summary |
Pleomorphic adenoma gene 1 encodes a zinc finger proteinwith 2 putative nuclear localization signals. PLAG1, which isdevelopmentally regulated, has been shown to be consistentlyrearranged in pleomorphic adenomas of the salivary glands. PLAG1 isactivated by the reciprocal chromosomal translocations involving8q12 in a subset of salivary gland pleomorphic adenomas. Threetranscript variants encoding two different isoforms have been foundfor this gene.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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