> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > TNFR-S274 AntibodyBrand |
Leading Biology | Catalog Number |
APR03531G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TNFR-S274 Antibody.
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Molecular Weight |
50495 Da
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Cellular Localization |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein Golgi apparatus membrane; Single- pass type I membrane protein Secreted. Note=A secreted form is produced through proteolytic processing
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
252-281 aa
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Target |
This TNFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 252-281 amino acids from human TNFR.
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Isotype |
Rabbit Ig
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Symbol |
TNFAR, TNFR1
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GeneID |
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UniProt ID |
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Function |
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
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Summary |
The protein encoded by this gene is a member of theTNF-receptor superfamily. This protein is one of the majorreceptors for the tumor necrosis factor-alpha. This receptor canactivate NF-kappaB, mediate apoptosis, and function as a regulatorof inflammation. Antiapoptotic protein BCL2-associated athanogene 4(BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown tointeract with this receptor, and thus play regulatory roles in thesignal transduction mediated by the receptor. Germline mutations ofthe extracellular domains of this receptor were found to beassociated with the autosomal dominant periodic fever syndrome. Theimpaired receptor clearance is thought to be a mechanism of thedisease.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, FC, E
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Dilution |
WB~~1:1000
FC~~1:10~50
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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