Leading Biology offers the unique native mouse monoclonal antibody discovery service for producing custom monoclonal antibodies by our Native™ Antibody Discovery Platform.

Mice are common experimental animals in laboratory research of biology and pharmacology. They belong to the order Rodentia and have been firstly used in biomedical research since 16th century. Currently, mice are recognized as the most commonly used mammalian model organism rather than rats. They are a kind of mammals which share a high degree of homology with humankind. Virtually, the sequencing analysis of mouse genome has shown that all mouse genes have human homologs, and they have similar antibody isotypes (IgA, IgD, IgE, IgG, and IgM) with humans. Thereby, mice’ s easy maintenance and handling, high reproduction rate and close relationship with human make they become particularly suitable for human-oriented research. In this way, people can aboveboard apply laboratory mice to some illegal manipulation of humans, so that they can obtain data which is highly similar or referable with that from humans, especially in physiology, genetics and immunology realm. In the booming field of drug discovery, laboratory mice are relied on both clinical animal test and monoclonal antibodies development.

The mouse monoclonal antibodies are widely used for therapeutics and pathology researches, but sometimes they may be limited due to their specificity and affinity. The aim of Leading Biology custom monoclonal antibody project is not only to generate a mouse monoclonal antibody that recognizes the immunizing antigen, but also to raise a large scale of antibodies with exceptionally high in vivo specificity and affinity that contribute to customers’ specific application. Through our exclusive Native Antibody Discovery Platform with antigen-specific B lymphocytes cytometry technology, a larger number of native antibody candidates, with in vivo paired heavy- and light-chains, can be isolated from antigen-specific plasma cells at once. And it should be considered as the most efficient way in developing native murine monoclonal antibodies by far.

Through this novel platform, Leading Biology can isolate naive-paired monoclonal antibodies from a wide range of host species:

Leading Biology, which has more than ten years’ experience for custom monoclonal antibody manufacturing, can provide one-stop service for clients from the antigen design process to the subsequent strategies required for the generation of desired native antibodies.