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Chloroplast/Mitochondrial Genome SequencingIntroduction
Plasmid and mitochondria are essential organelles in plant cells. Chloroplasts conduct photosynthesis in the presence of sunlight and mitochondria indirectly supply energy within plant cells; together they form the powerhouses of the cell. Both chloroplasts and mitochondria possess their own genomes. The chloroplast (cp) genome and mitochondrial (mt) genomes are often used for the study of plant evolution.
Chloroplast Genome Sequencing
Mitochondrial Genome Sequencing
Mitochondrial disorders are heterogeneous, inherited diseases that can arise at any stage of life. Studying mutations associated with mitochondrial disorders remains a challenge due to phenotypic variability and genetic heterogeneity among individuals. Mitochondrial sequencing with NGS technology addresses some of these challenges, enabling comprehensive detection and analysis of mitochondrial mutations.
Common NGS methods for analyzing mitochondrial disease-associated mutations include whole-exome sequencing and targeted gene sequencing. Whole-exome sequencing analyzes the protein-coding regions of the genome, with the capability to expand to include untranslated regions (UTRs) and microRNAs if desired. Targeted gene sequencing focuses on specific genes or gene regions of interest with known or suspected disease associations. Compare the two methods in the table below.
No | Headline | Click | Author | Date |
1 | Plant and Animal Whole Genome Re-Sequencing | 836 | Leading Biology | 2018-01-26 |
2 | Whole Exome Sequencing | 827 | Leading Biology | 2018-01-26 |
3 | Whole Transcriptome Shotgun Sequencing | 1140 | Leading Biology | 2018-01-26 |
4 | smallRNA/microRNA/circRNA/LncRNA Sequencing | 812 | Leading Biology | 2018-01-26 |
5 | Bacterial Genome Sequencing | 822 | Leading Biology | 2018-01-26 |
6 | Targeted Gene Sequencing | 922 | Leading Biology | 2018-01-26 |