> Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Human TNFRSF14 Protein(C-His Tag)Brand |
Leading Biology | Catalog Number |
PH0146M1 |
Product Type |
Cytokine | Field of Research |
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Nature |
Recombinant Protein
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Expression Host |
Mammalian cell
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Species |
Human
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AA Sequence |
NP_003811.2(Met 1-Val 202)
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Tags |
C-His
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Molecular Weight |
35KD
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Form |
lyophilized |
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Purity |
Greater than 95% by SDS-PAGE |
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Storage & Stability |
-70°C
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Storage Buffer |
0.2 μm filtered PBS, pH7.4
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Product Description |
The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network . Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation . Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions . Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response . In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and proinflammatory cytokines . Upon binding to CD160 on activated CD4+ T cells, downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response . May interact in cis (on the same cell) or in trans (on other cells) with BTLA (By similarity). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells .
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Synonyms |
ATAR Protein(Human); CD270 Protein(Human); HVEA Protein(Human); HVEM Protein(Human); LIGHTR Protein(Human); TR2 Protein(Human)
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Images |
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Quantity |
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| Select | Brand | Catalog No. | Product Name | Pack Size | Type | Field of Research | Specification | Quantity | Price(USD) | |
| 1 | Leading Biology | PH0003E1 | Recombinant Human TNF Alpha Protein | 10ug | Cytokine |
|
$195.00 | Add Ask | ||
| 2 | Leading Biology | PH0001E2 | Recombinant Human IL-6 Protein | 10ug | Cytokine |
|
$195.00 | Add Ask | ||
| 3 | Leading Biology | PH0073E2 | Recombinant Human CXCL2 Protein | 20μg | Cytokine |
|
$325.00 | Add Ask | ||
| 4 | Leading Biology | PH0041M1 | Recombinant Human IL-34 Protein (C-His Tag) | 20μg | Cytokine |
|
$325.00 | Add Ask | ||
| 5 | Leading Biology | PH0024E3 | Recombinant Human IL-16 Protein (N-His Tag) | 20μg | Cytokine |
|
$325.00 | Add Ask | ||
| 6 | Leading Biology | PM0036M1 | Recombinant Mouse IL-28A Protein (C-His Tag) | 20μg | Cytokine |
|
$325.00 | Add Ask |
Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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