> Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Human IL-37 ProteinBrand |
Leading Biology | Catalog Number |
PH0045E2 |
Product Type |
Cytokine | Field of Research |
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Nature |
Recombinant Protein
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Expression Host |
E.coli
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Species |
Human
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AA Sequence |
Q9NZH6-2(Lys 27-Asp 192)
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Tags |
Tag-Free
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Molecular Weight |
18KD
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Activity |
Measured by its binding ability in a functional ELISA.
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Form |
Lyophilized |
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Purity |
Greater than 95% by SDS-PAGE |
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Storage & Stability |
-70°C
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Storage Buffer |
0.2 μm filtered PBS, pH7.4
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Product Description |
Interleukin-37 (IL-37) is a natural inhibitor of immune and inflammatory responses and is involved as an anti-inflammatory factor in immune and inflammatory responses. IL-37 is a cytokine with both intracellular and extracellular functions. Its inhibitory inflammatory response and its involvement in immune regulation are mainly: IL-37 precursor is cleaved by cysteine-1 (Caspase-1). It becomes an active mature body, IL-37b, which enhances the inhibitory effect of 1L-18BP on IL-18 by binding to IL-18 binding protein (IL-18BP), thereby inhibiting interferon-Y (IF-N-γ) Generation; IL-37b transfer to cells to bind to smad3 to form IL-37b-Smad3 complex, thereby reducing the expression of some inflammatory signaling pathway-related kinases such as FAK, MAPK p38 and c-Jun.
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Synonyms |
FIL1 Protein (Human); FIL1Z Protein (Human); IL-1F7 Protein (Human); IL-1H Protein (Human); IL-1H4 Protein (Human); IL-1RP1 Protein (Human)
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Images |
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Quantity |
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Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
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