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Recombinant Human CXCL2 ProteinBrand |
Leading Biology | Catalog Number |
PH0073E2 |
Product Type |
Cytokine | Field of Research |
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Nature |
Recombinant Protein
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Expression Host |
E.coli
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Species |
Human
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AA Sequence |
NP_002080.1(Ala35-Asn107)
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Tags |
Tag-Free
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Molecular Weight |
8KD
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Activity |
Measured by its ability to induce myeloperoxidase release from cytochalasin B-treated human neutrophils.
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Form |
lyophilized |
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Purity |
Greater than 95% by SDS-PAGE |
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Storage & Stability |
-70°C
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Storage Buffer |
0.2 μm filtered 20 mM Tris, 1 M NaCl, pH 8.0
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Product Description |
Chemokine (C-X-C motif) ligand 2 (CXCL2) is a small cytokine belonging to the CXC chemokine family that is also called macrophage inflammatory protein 2-alpha (MIP2-alpha), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2). CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. This chemokine is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines. CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2. CXCL2, like related chemokines, is also a powerful neutrophil chemoattractant and is involved in many immune responses including wound healing, cancer metastasis, and angiogenesis. A study was published in 2013 testing the role of CXCL2, CXCL3, and CXCL1 in the migration of airway smooth muscle cells (ASMCs) migration which plays a significant role in asthma. The results of this study showed that CXCL2 and CXCL3 both help with the mediation of normal and asthmatic ASMC migration through different mechanisms.
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Synonyms |
CINC-2a Protein(Human); GRO2 Protein(Human); GROb Protein(Human); MGSA-b Protein(Human); MIP-2a Protein(Human); MIP2 Protein(Human); MIP2A Protein(Human); SCYB2 Protein(Human)
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Images |
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Quantity |
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