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Location: Home > Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Human CXCL2 Protein

Recombinant Human CXCL2 Protein

PH0073E2
Catalog # Availability Size / Price Inquiry
PH0073E2-20μg 20μg / $325
PH0073E2-100μg 100μg / $955

Recombinant Human CXCL2 Protein

Brand

Leading Biology

Catalog Number

PH0073E2

Product Type

Cytokine

Field of Research

Nature

Recombinant Protein

Expression Host

E.coli

Species

Human

AA Sequence

NP_002080.1(Ala35-Asn107)

Tags

Tag-Free

Molecular Weight

8KD

Activity

Measured by its ability to induce myeloperoxidase release from cytochalasin B-treated human neutrophils.

Form

lyophilized

Purity

Greater than 95% by SDS-PAGE

Storage & Stability

-70°C

Storage Buffer

0.2 μm filtered 20 mM Tris, 1 M NaCl, pH 8.0

Product Description

Chemokine (C-X-C motif) ligand 2 (CXCL2) is a small cytokine belonging to the CXC chemokine family that is also called macrophage inflammatory protein 2-alpha (MIP2-alpha), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2). CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. This chemokine is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines. CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2. CXCL2, like related chemokines, is also a powerful neutrophil chemoattractant and is involved in many immune responses including wound healing, cancer metastasis, and angiogenesis. A study was published in 2013 testing the role of CXCL2, CXCL3, and CXCL1 in the migration of airway smooth muscle cells (ASMCs) migration which plays a significant role in asthma. The results of this study showed that CXCL2 and CXCL3 both help with the mediation of normal and asthmatic ASMC migration through different mechanisms.

Synonyms

CINC-2a Protein(Human); GRO2 Protein(Human); GROb Protein(Human); MGSA-b Protein(Human); MIP-2a Protein(Human); MIP2 Protein(Human); MIP2A Protein(Human); SCYB2 Protein(Human)

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Quantity

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